Racial Differences in Genomic Profiling of Prostate Cancer

Racial Differences in Genomic Profiling of Prostate Cancer

Authors Mahal BA, Alshalalfa M, Kensler KH, Chowdhury-Paulino I, Kantoff P, Mucci LA, Schaeffer EM, Spratt D, Yamoah K, Nguyen PL, Rebbeck TR.


TO THE EDITOR:

The incidence of prostate cancer and its associated mortality vary widely according to race or ethnic background.1 This association is probably due to the interplay of socioeconomic factors, environmental exposures, and biologic and epigenetic phenomena.1,2 Nevertheless, precision oncologic studies have underrepresented Black and other non-White patients, thereby limiting our comprehensive understanding of disparities in the diagnosis and prognosis of prostate cancer among these populations.3 Therefore, we examined tumor genomic profiles across race in a diverse cohort of patients.

First, we reviewed tumor genomic data obtained with the use of next-generation sequencing from patients who had been treated for prostate cancer at either Memorial Sloan Kettering Cancer Center or Dana–Farber Cancer Institute. These data were extracted from the registry of the American Association for Cancer Research Project GENIE (Genomics Evidence Neoplasia Information Exchange), version 7.0.4 Mutational profiles of 474 genes were examined according to race (White, Black, or Asian) and tumor stage (primary or metastatic). We used the Benjamini–Hochberg method to control for the false discovery rate.


Among 2393 patients (2109 White, 204 Black, and 80 Asian), 1484 had primary disease (1308 White, 133 Black, and 43 Asian) and 909 had metastatic disease (801 White, 71 Black, and 37 Asian). The mutational profiles of the patients are shown in Figure 1; the relative difference in mutations in primary disease and in metastatic disease according to race are shown in Figure S1 in the Supplementary Appendix.

Among the patients with primary prostate cancers, 11.5% of Asian men had more than 20 mutations (Figure 1A). FOXA1 mutations occurred more often in Black men than in White men (18.6% vs. 11.9%; unadjusted between-group difference [referred to as difference throughout], 6.7 percentage points; 95% confidence interval [CI], 0.8 to 13.5; P=0.03); such mutations also occurred more frequently in Asian men (37.8% vs. 11.9%; difference, 25.9 percentage points; 95% CI, 10.2 to 41.7; P<0.001) (Figure 1C). TP53 mutations occurred less frequently in Black men than in White men (14.2% vs. 20.6%; difference, −6.4 percentage points; 95% CI, −12.7 to 0; P=0.045). Mutations in the gene encoding androgen receptor (AR) were rare, regardless of race. The frequencies of genes with actionable mutations (i.e., alterations that are the intended targets of precision-oncology drugs) and mutations in DNA-repair genes did not differ substantially among the racial groups (Figure 1E).


Among the patients with metastatic prostate cancer, 6.8% of Black men had more than 20 mutations (Figure 1B). AR mutations occurred more often in Black men than in White men (18.3% vs. 8.1%; difference, 10.2 percentage points; 95% CI, 1.0 to 19.4; P=0.004) (Figure 1D). TP53 mutations occurred more often in Asian men than in either Black men (62.0% vs. 22.5%; difference, 49.5 percentage points; 95% CI, 21.2 to 58.0; P=0.008) or White men (62.0% vs. 36.4%; difference, 25.6 percentage points; 95% CI, 9.7 to 41.7; P=0.004). Genes with actionable mutations occurred more often in Black men than in White men (26.7% vs. 18.0%; difference, 8.7 percentage points; 95% CI, 0 to 19.5; P=0.05), as did mutations in DNA-repair genes (22.5% vs. 15.6%; difference, 6.9 percentage points; 95% CI, 0.5 to 18.1; P=0.05) (Figure 1F). In addition, BRAF mutations, which are rare in prostate cancer and are considered to be actionable in many tumor sites, were also more frequent in Black men than in White men (7.0% vs. 1.5%; difference, 5.5 percentage points; 95% CI, 0.4 to 11.5; P=0.002).


Clinically significant alterations may occur at different frequencies across races. Notably, Black men with metastatic prostate cancer were more likely than either White or Asian men to have tumor mutations in AR, along with mutations in DNA-repair genes and actionable genetic mutations. This finding could have implications for prognosis, response to therapy, and enrollment of minority populations in clinical trials and precision oncology studies.3,5 Our study was limited by its use of confidence intervals that were not adjusted for multiple comparisons. To support and further explore the implications of these findings, we will need studies involving a larger number of non-White men for whom data are available regarding the effects of treatment and results from histopathological analysis on outcomes. The evaluation of such data could help to prevent a worsening of racial disparities in the diagnosis and treatment of prostate cancer.3


Full journal article here: https://www.nejm.org/doi/10.1056/NEJMc2000069?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed


(Details regarding methods are provided in the Supplementary Appendix, available with the full text of this letter at NEJM.org.)


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