Prostate Cancer Genomic-risk Differences Between African-American and White Men Across Gleason Scores
Brandon A Mahal, Mohammed Alshalalfa, Daniel E Spratt, Elai Davicioni, Shuang G Zhao, Felix Y Feng, Timothy R Rebbeck, Paul L Nguyen, Franklin W Huang
African-American men have poorer prostate cancer-specific outcomes compared with white men . Emerging evidence suggests that racial disparities in advanced stage or higher-grade disease may be predominantly accounted for by social factors and healthcare access [2,3]. In contrast, there is growing evidence to support the hypothesis that disparities in low-grade Gleason 6 disease may be in part driven by underlying tumor differences [3,4]. Although low-grade (Gleason 6) disease is considered prognostically favorable, it is associated with a diverse genomic landscape that can sometimes include aggressive genomic features .