Axiom Pan-African Cancer Research Array

Driving deeper insights into genetic factors associated with cancer

Array content summary

The Applied Biosystems™ Axiom™ Pan-African Cancer

Research Array was developed with the Men of African

Descent and Carcinoma of the Prostate (MADCaP)

Consortium to enable better association of genetic variants

with prostate and other cancers in African populations.

The Axiom Pan-African Cancer Research Array provides

high coverage of common as well as low-frequency wholegenome

variants across diverse African populations [1], and

high coverage across all 1000 Genomes phase 3 super

populations. As part of the design strategy, the array was

enriched for comprehensive coverage of variants that are

polymorphic in African populations, including 18 ethnolinguistic

groups from Sub-Saharan Africa [2,3].

Carcinoma of the prostate (CaP) disproportionately

affects men of African descent and is a leading cause of

death among them. Genome-wide association studies

(GWAS) have identified over 200 loci relevant to CaP, but

underrepresentation of African populations means that

many relevant genetic variations are not captured [3-5]. The

Axiom Pan-African Cancer Research Array addresses this

gap by offering over 1.5 million markers across two arrays

and an imputation-aware GWAS grid that tags over 94%

variants commonly found in African populations.

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