Driving deeper insights into genetic factors associated with cancer
Array content summary
The Applied Biosystemsâ„¢ Axiomâ„¢ Pan-African Cancer
Research Array was developed with the Men of African
Descent and Carcinoma of the Prostate (MADCaP)
Consortium to enable better association of genetic variants
with prostate and other cancers in African populations.
The Axiom Pan-African Cancer Research Array provides
high coverage of common as well as low-frequency wholegenome
variants across diverse African populations [1], and
high coverage across all 1000 Genomes phase 3 super
populations. As part of the design strategy, the array was
enriched for comprehensive coverage of variants that are
polymorphic in African populations, including 18 ethnolinguistic
groups from Sub-Saharan Africa [2,3].
Carcinoma of the prostate (CaP) disproportionately
affects men of African descent and is a leading cause of
death among them. Genome-wide association studies
(GWAS) have identified over 200 loci relevant to CaP, but
underrepresentation of African populations means that
many relevant genetic variations are not captured [3-5]. The
Axiom Pan-African Cancer Research Array addresses this
gap by offering over 1.5 million markers across two arrays
and an imputation-aware GWAS grid that tags over 94%
variants commonly found in African populations.
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